CoFactor: The organic enzyme cofactor database
Aug 15, 2010
The CoFactor database has an awesome logo. In addition, the database is a source of publications and mechanisms of organic enzyme cofactors (ref). The CoFactor database is related to the MACiE project which has already brought together hundreds of annotated enzymatic reactions. The database is still in the early stages, but if you work with an enzyme that has an organic substrate then it is worth keeping an eye on.
The database currently contains the following molecules:
- Adenosylobalamin (Vitamin B12)
- Ascorbic acid (Vitamin C)
- Biopterin
- Biotin
- Coenzyme A (CoA)
- Coenzyme B
- Coenzyme M
- Dipyrromethane
- Factor F430
- Flavin Adenine Dinucleotide (FAD)
- Flavin Mononucleotide (FMN)
- Glutathione (GSH)
- Flavin adenine mononucletide
- Heme
- Lipoic acid
- Menaquinone (Vitamin K)
- MIO cofactor
- Molybdopterin
- Orthoquinone residues (TTQ, LTQ and CTQ)
- Phosphopantethenic acid
- Pyridoxal 5′-phosphate (PLP)
- Pyrroloquinoline Quinone (PQQ)
- Nicotinamide-adenosine dinucleotide (NAD)
- S-adenosylmethionine
- Tetrahydrofolic acid (THF)
- Thiamine diphosphate (ThDP)
- Topaquinone (TPQ)
- Ubiquinone (CoQ)
The output contains a diagram of the molecule, molecular functions, chemical pathways and references. My favorite enzymic database is still BRENDA (just updated last month), but it’s nice to see some newcomers.